Vildagliptin dihydrate
Vildagliptin dihydrate
CAS: 2133364-01-7
Molecular Formula: C17H27N3O3
Vildagliptin dihydrate - Names and Identifiers
| Name | Vildagliptin dihydrate |
| Synonyms | 2133364-01-7 Vildagliptin dihydrate |
| CAS | 2133364-01-7 |
Vildagliptin dihydrate - Physico-chemical Properties
| Molecular Formula | C17H27N3O3 |
| Molar Mass | 321.42 |
| Storage Condition | 2-8℃ |
| Use | Vildagliptin (LAF237 dihydrate;NVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor, which can be prolonged |
| In vitro study | Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation. |
| In vivo study | Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice. Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats. Animal Model: Male db/db mice (BKS) and wildtype mice Dosage: 35 mg/kg Administration: Oral gavage; once daily; for 6 weeks Result: Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44). Animal Model: Obese male Zucker rats Dosage: 10 µmol/kg (Pharmacokinetic Analysis) Administration: Orally Result: Significantly decreased glucose excursions and stimulate insulin secretion. |
